OUR VISION

ABOUT

The UCLA Center for LGBTQ+ Advocacy, Research & Health, or C-LARAH (LARAH is derived from the Latin word “hilaris,” meaning cheerful) is dedicated to improving the health and well-being of sexual and gender minorities.  We are committed to sharing our expertise in public health, including epidemiological methods, developing and testing bio-behavioral interventions, education and research training, program design and analysis, health policy initiatives and implementation science.  We work directly with members of the LGBTQ+ community and are able to draw upon expansive local and national relationships with state and local public health departments, academic researchers, healthcare providers, community-based organizations, consumer groups, advocacy foundations, and funding agencies.  Our familiarity and experience working with the LGBTQ+ community and allied organizations well-equips us to inform policymakers of the most effectual ways to reach members of this historically marginalized population and how to serve them holistically through all social determinants of health and justice.

Mission Statement

To maintain an interdisciplinary, research-driven, evidence-based platform used to carry out public policy initiatives that improve the health and social well-being of sexual and gender minorities. We engage our local and national community, as well as global partners, through cross-culturally informed scholarship, advanced academic training, and civic advocacy. We are deeply invested in intercultural competence and the importance of intersectionality of identities and lived experience; we are committed to conducting research to advance LGBTQ+ racial/ethnic health disparities.

DR. MATTHEW J. MIMIAGA

DIRECTOR’S MESSAGE

“Sexual and gender minorities experience significant health disparities as a result of myriad overlapping social-ecological, cultural, and political factors. Research findings by our team and others demonstrate that LGBTQ+ populations have a higher prevalence and incidence of life-threatening physical conditions, as well as chronic and infectious diseases. Despite recent advances in civil rights protections in some states, LGBTQ+ individuals continue to face elevated rates of stigma, discrimination, and violence, which contribute to higher rates of mental health problems and, consequently, increased substance use—often employed as a coping mechanism. They are disproportionately represented among homeless populations—often due to estrangement from their families—and encounter significant barriers to accessing healthcare, prevention, and treatment services.

Now is the time for academic institutions to strengthen the unwavering efforts toward progress made by the LGBTQ+ movement. We must bridge health, research, and training initiatives to address socioeconomic inequities, close the health disparity gap, and oppose discriminatory policies enacted by the current administration. Over the past four decades, we have advocated tirelessly for LGBTQ+ rights—indeed, for their basic humanity—and we must continue to demand accountability in shaping and enforcing policies that best serve our community.

It is deeply rewarding to be involved in work that improves the lives of historically marginalized members of society. I am excited about the impact C-LARAH has had—and will continue to have—in training future generations of scientists interested in conducting LGBTQ+ public health and clinical research, and ensuring that all sexual and gender minorities, particularly transgender individuals, racial and ethnic minorities, and those living with, and at risk of, HIV, belong everywhere, can live openly and authentically, and be healthy.”

Training

Research Excellence

C-LARAH is committed to a collaborative and inclusive environment where students, post-doctoral fellows, and other mentees from diverse backgrounds are trained to thrive as leaders in LGBTQ+ public health, epidemiological methods, and behavioral science, and where students, postdocs, staff and faculty are valued regardless of race, ethnicity, religion, socio-economic position, first-generation college student, immigration status, gender identity, sexual identity, or disability. 

C-LARAH is devoted to recruiting and training a community of diverse scholars from underrepresented minority groups and fostering a welcoming, inclusive and intellectually-enriching environment where all students, postdocs, staff and faculty feel supported and can achieve their full potential.  Furthermore, we are dedicated to prioritizing our reach and understanding of diverse populations and communities in our research, scholarship and training programs, and advancing diversity, equity and inclusion in the field of LGBTQ+ public health.

Promoting research excellence and addressing diversity in our work setting is integral to our initiatives as a Center. It broadens and deepens the training experience and scholarly environment for students, postdocs and faculty alike. Our primary commitment to our students and postdocs is to provide an all-encompassing research training experience that is based on the principles of equity and inclusion of all individuals; within the Center environment, differences are acknowledged as contributions and individuals are respected for their beliefs and cultural practices. 

The Latest

Announcements

  • Statements
  • Events
  • Community Highlights
New Featured Statement: Honoring Juneteenth

New Featured Statement: Honoring Juneteenth

Honoring Juneteenth: A Day of Freedom, Reflection, and Resistance

Today, on Juneteenth, the UCLA Center for LGBTQ+ Advocacy, Research & Health (C-LARAH) honors the enduring legacy of Black freedom fighters who have paved the way toward liberation, justice, and equity in the face of systemic oppression.

June 19, 1865 — more than two years after the Emancipation Proclamation — marked the delayed freedom of enslaved Black Americans in Galveston, Texas. Juneteenth is not just a commemoration of emancipation, but a reminder of the ongoing struggle for Black liberation across all systems and institutions.

As a center rooted in public health, advocacy, and justice, we affirm that Black Lives Matter and that the health and well-being of Black LGBTQ+ individuals must remain central in our work. The intersecting legacies of racism, homophobia, and transphobia continue to shape lived experiences, and we remain committed to dismantling those barriers through research, policy, and community-rooted care.

Today, we reflect, recommit, and raise our voices in solidarity. Juneteenth is a call to action — to imagine and fight for a future where freedom is truly for all.

In community and with purpose,
The UCLA Center for LGBTQ+ Advocacy, Research & Health (C-LARAH)

Read More Statements

Statements
Featured Event: UCLA Spring Grad LGBTQ+ Pride Mixer

Featured Event: UCLA Spring Grad LGBTQ+ Pride Mixer

On June 6th, 2025, C-LARAH co-sponsored the Inaugural UCLA Spring Grad LGBTQ+ Pride Mixer—a celebration of Unapologetic Joy. This special event honored both the end of the academic year and the beginning of Pride Month, creating a vibrant and affirming space for LGBTQ+ and allied graduate students from across UCLA to come together, connect, and celebrate. In a time when queer joy is both necessary and revolutionary, this mixer centered visibility, community, and celebration across disciplines and identities.

Designed as a cocktail-style gathering, the event featured music, complimentary food and an open bar, rainbow-themed giveaways, and a keynote speaker Freddy Puza, the Vice Mayer of Culver City.

This event was proudly hosted by OUT@Fielding, Out@Anderson, the Center for LGBTQ+ Advocacy, Research and Health (C-LARAH), the Graduate Student Association (GSA), the Graduate Student Resource Center (GSRC), and the Pride Alliance at DGSOM, with additional support from UCLA’s wider graduate, LGBTQ+, and equity, diversity, and inclusion (EDI) community.

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Events
New Featured Community Highlight: Dr. Yuhang Qian, PhD

New Featured Community Highlight: Dr. Yuhang Qian, PhD

Congratulations to Dr. Yuhang Qian for completing his PhD in Epidemiology at UCLA!

Your achievement is an inspiration, and we look forward to your future successes!

See More Community Highlights

Community Highlights
PEOPLE

The
Team

  • CENTER FACULTY, STAFF & STUDENTS
  • UCLA Faculty Affiliates
  • Main Collaborators
  • C-LARAH / UCLA Alumni
Matthew Mimiaga, ScD, MPH, MA (he/him)

Matthew Mimiaga, ScD, MPH, MA (he/him)

CENTER FACULTY, STAFF & STUDENTS Faculty
Roger Detels, MD, MS (he/him)

Roger Detels, MD, MS (he/him)

CENTER FACULTY, STAFF & STUDENTS
Kiana Aminzadeh, BS, BA (she/her)

Kiana Aminzadeh, BS, BA (she/her)

CENTER FACULTY, STAFF & STUDENTS C-LARAH / UCLA Alumni
Jackie Andrzejewski, PhD, MPH (they/them)

Jackie Andrzejewski, PhD, MPH (they/them)

CENTER FACULTY, STAFF & STUDENTS
Chantel Delshad Azarkman, BS

Chantel Delshad Azarkman, BS

CENTER FACULTY, STAFF & STUDENTS
Najib Aziz, MD

Najib Aziz, MD

C-LARAH / UCLA Alumni
Marvin Belzer, MD

Marvin Belzer, MD

Main Collaborators
Jessica Bernacki, PhD

Jessica Bernacki, PhD

UCLA Faculty Affiliates
Katie Biello, PhD, MPH

Katie Biello, PhD, MPH

Main Collaborators
Sarah Blankespoor, BS (they/them)

Sarah Blankespoor, BS (they/them)

CENTER FACULTY, STAFF & STUDENTS
Callisto Boka, MS (he/him)

Callisto Boka, MS (he/him)

C-LARAH / UCLA Alumni
Ronald Brooks, PhD

Ronald Brooks, PhD

UCLA Faculty Affiliates
Daniel Cheng, BS

Daniel Cheng, BS

CENTER FACULTY, STAFF & STUDENTS
Izzy Chiu, MPH

Izzy Chiu, MPH

C-LARAH / UCLA Alumni
Andy Cofino, MA

Andy Cofino, MA

UCLA Faculty Affiliates
Charles Doran, BS (he/him)

Charles Doran, BS (he/him)

CENTER FACULTY, STAFF & STUDENTS
Marta Epeldegui, PhD

Marta Epeldegui, PhD

UCLA Faculty Affiliates
Allen Ernst, BS

Allen Ernst, BS

CENTER FACULTY, STAFF & STUDENTS
Jack Feng, MHS (he/him)

Jack Feng, MHS (he/him)

CENTER FACULTY, STAFF & STUDENTS
Chandra Ford, PhD, MPH, MLIS

Chandra Ford, PhD, MPH, MLIS

UCLA Faculty Affiliates
Candelaria Garcia, MPH

Candelaria Garcia, MPH

C-LARAH / UCLA Alumni
Robert Garofolo, MD, MPH

Robert Garofolo, MD, MPH

Main Collaborators
Kevin D. Goodman, PhD, MS

Kevin D. Goodman, PhD, MS

UCLA Faculty Affiliates
Mary Guze, MPH (she/her)

Mary Guze, MPH (she/her)

CENTER FACULTY, STAFF & STUDENTS
Stephanie Ha, BS (she/her)

Stephanie Ha, BS (she/her)

CENTER FACULTY, STAFF & STUDENTS
Nicole Hadjioannou, MPH (she/her)

Nicole Hadjioannou, MPH (she/her)

CENTER FACULTY, STAFF & STUDENTS
Marco Hidalgo, PhD (he/him & they/them)

Marco Hidalgo, PhD (he/him & they/them)

CENTER FACULTY, STAFF & STUDENTS
Ian Holloway, PhD, LCSW, MPH

Ian Holloway, PhD, LCSW, MPH

UCLA Faculty Affiliates
Jimmy Hua, MPH

Jimmy Hua, MPH

C-LARAH / UCLA Alumni
Nicolas Hudin, BS

Nicolas Hudin, BS

CENTER FACULTY, STAFF & STUDENTS
Brandon Ito, MD, MPH

Brandon Ito, MD, MPH

UCLA Faculty Affiliates
Lisa Kuhns, PhD, MPH

Lisa Kuhns, PhD, MPH

Main Collaborators
Eun Kwak, BS

Eun Kwak, BS

CENTER FACULTY, STAFF & STUDENTS Staff
Sung-Jae Lee, PhD, MPH

Sung-Jae Lee, PhD, MPH

UCLA Faculty Affiliates
Liz Lopez, MA

Liz Lopez, MA

UCLA Faculty Affiliates
Jeremy Martinez, BS

Jeremy Martinez, BS

CENTER FACULTY, STAFF & STUDENTS
Kenneth H. Mayer, MD

Kenneth H. Mayer, MD

Main Collaborators
Zaya Mejia, BA (she/her)

Zaya Mejia, BA (she/her)

CENTER FACULTY, STAFF & STUDENTS
Raymundo Mercado, BS

Raymundo Mercado, BS

C-LARAH / UCLA Alumni
Ilan Meyer, PhD

Ilan Meyer, PhD

UCLA Faculty Affiliates
Hayden Mountcastle, MPH

Hayden Mountcastle, MPH

C-LARAH / UCLA Alumni
Destiny Negrete, BS

Destiny Negrete, BS

CENTER FACULTY, STAFF & STUDENTS
Ellie Nelson, BS

Ellie Nelson, BS

C-LARAH / UCLA Alumni
Gladys Ng, MD, MPH

Gladys Ng, MD, MPH

UCLA Faculty Affiliates
Andre Nguyen, EdM

Andre Nguyen, EdM

C-LARAH / UCLA Alumni
Nikki Sarmah, MPH

Nikki Sarmah, MPH

CENTER FACULTY, STAFF & STUDENTS
G Noori, MD, MPH

G Noori, MD, MPH

CENTER FACULTY, STAFF & STUDENTS
Gifty Ntim, MD

Gifty Ntim, MD

UCLA Faculty Affiliates
Conall O’Cleirigh, PhD

Conall O’Cleirigh, PhD

Main Collaborators
Ayako Miyashita Ochoa, JD

Ayako Miyashita Ochoa, JD

UCLA Faculty Affiliates
John Oishi, MSPH

John Oishi, MSPH

C-LARAH / UCLA Alumni
Elizabeth Ollen, PhD, MA

Elizabeth Ollen, PhD, MA

UCLA Faculty Affiliates
Carolina Cormack Orellana, MSW (she/her)

Carolina Cormack Orellana, MSW (she/her)

CENTER FACULTY, STAFF & STUDENTS
Emari Oyola, BA (she/her)

Emari Oyola, BA (she/her)

Janet Pregler, MD

Janet Pregler, MD

UCLA Faculty Affiliates
Yuhang Qian, PhD, MHS (he/him)

Yuhang Qian, PhD, MHS (he/him)

C-LARAH / UCLA Alumni
Sari L. Reisner, ScD, MA

Sari L. Reisner, ScD, MA

Main Collaborators
Roxana Rezai, PhD, MPH (she/her)

Roxana Rezai, PhD, MPH (she/her)

CENTER FACULTY, STAFF & STUDENTS C-LARAH / UCLA Alumni
Olive Rickett, MPH (she/her & they/them)

Olive Rickett, MPH (she/her & they/them)

CENTER FACULTY, STAFF & STUDENTS
Amy Ritterbusch, PhD

Amy Ritterbusch, PhD

UCLA Faculty Affiliates
Steven Safren, PhD

Steven Safren, PhD

Main Collaborators
Carlos Santos, PhD, MEd

Carlos Santos, PhD, MEd

UCLA Faculty Affiliates
West Seegmiller, BA

West Seegmiller, BA

C-LARAH / UCLA Alumni
Roger Shih, MPH (he/him)

Roger Shih, MPH (he/him)

CENTER FACULTY, STAFF & STUDENTS
Chelsea Leigh Shover, PhD

Chelsea Leigh Shover, PhD

UCLA Faculty Affiliates
Juan Solis, MPH

Juan Solis, MPH

C-LARAH / UCLA Alumni
Rey Soto, BS

Rey Soto, BS

CENTER FACULTY, STAFF & STUDENTS
Dallas Swendeman, PhD, MPH

Dallas Swendeman, PhD, MPH

UCLA Faculty Affiliates
Keyanna Taylor, MPH, MS

Keyanna Taylor, MPH, MS

C-LARAH / UCLA Alumni
Jiahao Tian, MS (he/him)

Jiahao Tian, MS (he/him)

CENTER FACULTY, STAFF & STUDENTS
Eric Trigg

Eric Trigg

CENTER FACULTY, STAFF & STUDENTS
David Vargas Ayala, MPH

David Vargas Ayala, MPH

C-LARAH / UCLA Alumni
Amy Weimer, MD

Amy Weimer, MD

UCLA Faculty Affiliates
Jaclyn White-Hughto, PhD, MPH

Jaclyn White-Hughto, PhD, MPH

Main Collaborators
William Lodge II, PhD, ScM

William Lodge II, PhD, ScM

C-LARAH / UCLA Alumni
Bianca D.M. Wilson, PhD

Bianca D.M. Wilson, PhD

UCLA Faculty Affiliates
Connor Wright, MPH (he/him)

Connor Wright, MPH (he/him)

CENTER FACULTY, STAFF & STUDENTS
Beverly Yang, MPH

Beverly Yang, MPH

CENTER FACULTY, STAFF & STUDENTS
Elizabeth Yonko, MPH (she/her & they/them)

Elizabeth Yonko, MPH (she/her & they/them)

CENTER FACULTY, STAFF & STUDENTS
OUR RESEARCH

Our Projects

PrEPare for Work Pilot

PrEPare for Work Pilot

PrEPare for Work Pilot

Optimizing PrEP Uptake & Adherence Among MSW Using a 2-Stage Randomization Design, 2016-2020

MPI: Mimiaga, Biello & Chan

National Institute of Mental Health (R34MH110369-01 + diversity supplement)
we designed the “PrEPare for Work” package that includes two components: 1) peer-led strengths-based case management (SBCM) for PrEP uptake, and 2) a counseling and problem-solving PrEP adherence intervention that addresses individualized barriers to optimal use. We conducted a pilot RCT of “PrEPare for Work” using a two-stage randomization design. Stage 1: 106 MSW were equally randomized to receive either the peer-led SBCM or standard of care (i.e., passive referrals only) for engagement with our existing PrEP clinic. Stage 2: Those from stage 1 who initiated PrEP (n~44), regardless of stage 1 randomization condition, were equally randomized to either the “PrEPare for Work” adherence intervention or standard of care comparison condition.
Findings provide evidence of feasibility and acceptability, and demonstrate initial efficacy for PrEP uptake and adherence.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper: Under Review
Secondary Outcome Paper 1
Secondary Outcome Paper 2

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Selected Completed Studies
Project IMPACT

Project IMPACT

Project IMPACT

Name of Grant

Integrated behavioral activation and HIV risk reduction counseling for MSM with stimulant abuse

Funding Source

National Institute on Drug Abuse (R01DA042805-01A1)

Pls

Mimiaga and Safren

Background

Problematic stimulant (i.e., crystal methamphetamine [meth], cocaine, crack) use is a prevalent and treatment refractory problem in some men who have sex with men (MSM), and highly predictive of both condomless sex and HIV infection. This application builds off of our successful formative and pilot work and is designed to assess the efficacy, in a two-arm randomized controlled trial (RCT), of Project IMPACT—a behavioral intervention to reduce high-risk sex in MSM with stimulant use disorder who are at risk for HIV acquisition. The intervention incorporates risk reduction counseling with behavioral activation (BA) to help participants re-engage in enjoyable and meaningful life activities not involving drugs. Behavioral activation is an evidence-based, easy to administer, cognitive behavioral approach to treat depression and other problems that focuses on helping individuals reengage in activities that generate feelings of enjoyment (i.e., mastery and pleasure). We chose this strategy for MSM with stimulant use disorder because our formative work revealed that MSM who abuse stimulants report becoming unable to enjoy activities that they previously enjoyed as a result of ongoing stimulant use. This lack of enjoyment (i.e., anhedonia, one of the core symptoms of depression) in activities that do not involve stimulant use or sex contributes to the continued use of stimulants and potentially condomless sex (not protected by PrEP). We developed and openly field-tested this intervention in a NIDA-funded nonrandomized pilot (R03 DA023393), and, subsequently, conducted a NIDA-funded pilot RCT (R34 DA031028) of this intervention compared to a standard of care condition (SOC) and found it to be feasible, acceptable, and successful at reducing both condomless anal sex and stimulant use. The proposed efficacy trial is the next logical step in this program of research.

Conceptual Model

The conceptual model focuses on anhedonia—a loss of interest in previously enjoyed activities—as a consequence of continued stimulant use. Accordingly, for individuals with stimulant use disorder, drug use becomes the central means for obtaining enjoyment, and hence BA will augment HIV risk reduction counseling.

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PrEP N’ Shine

PrEP N’ Shine

PrEP N' Shine

Name of Grant

Developing and pilot testing an adaptive intervention to facilitate PrEP uptake and maximize PrEP adherence among at-risk transgender women.

Funding Source

National Institute of Mental Health (R34 MH122499-01A1)

Pls

Mimiaga and Biello

Background

PrEP has dramatically changed the promise of HIV prevention, particularly for transgender women (TGW) who are among the highest risk group for HIV in the U.S. While PrEP reduces HIV acquisition by >90% with adequate adherence, TGW face multiple transgender-specific barriers with PrEP access, uptake, adherence, and retention. The PIs have longstanding partnerships with community-based organizations that provide gender-affirming services to this group in Providence, RI and operate one of the first clinical PrEP programs in the U.S., led by our team at Miriam Hospital/Brown University.

Conceptual Model

The intervention package (“PrEP N’ Shine”) is based on over a decade of formative and programmatic work grounded in the social-cognitive and contextual realities of high-risk TGW, and as such, the conceptual model underlying the intervention draws on Empowerment Theory and Social Cognitive Theory. The “PrEP N’ Shine” package includes two separate but complementary interventions: 1) peer-led, strengths-based case management (SBCM) for PrEP linkage and uptake; and 2) a resource-efficient, adaptive “stepped-care” technology and counseling intervention to optimize PrEP adherence. “Stepped-care” is a healthcare delivery model in which the least resource intensive part of an intervention is delivered first, and only those who continue to have problems adhering to PrEP receive the more resource-intensive components.

Approach

Initially, we will continue to work with community members and a community advisory board to further inform the “PrEP N’ Shine” intervention (Aim 1a). Next, we will iteratively refine the intervention, in an open pilot trial with exit interviews, with up to 10 TGW to enhance participant acceptability, feasibility of study procedures, and finalize study protocols (Aim 1b). For Aim 2, we will conduct a pilot randomized controlled trial (RCT) of the “PrEP N’ Shine” intervention using a 2-stage randomization design: For Stage 1, we aim randomize 106 TGW who are candidates for PrEP to receive either the peer-led SBCM for PrEP linkage and uptake or standard of care (SOC; i.e., PrEP referrals only). For Stage 2, those from Stage 1 who initiate PrEP (n~44), regardless of their randomization condition, will then be equally re-randomized to either the resource-efficient, adaptive “stepped-care” intervention to optimize PrEP adherence (initially TGW in this arm will receive daily 2-way gender-affirming text message reminders, and then those continuing to have poor adherence will receive the 4 more intensive counseling sessions) or the SOC condition. Primary outcomes include PrEP linkage and uptake; PrEP adherence (both biomedical and self-report assessments); and retention in PrEP care.

Innovation

The “PrEP N’ Shine” intervention is highly scalable and sustainable in the real world, as it takes into account the “future of PrEP access,” while simultaneously 1) addressing the barriers surrounding access, 2) aiding in navigating linkage, and for those who need it, both insurance and free PrEP program options, and 3) reducing barriers to, and building skills to support, PrEP adherence (once TGW have access to PrEP).

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Positive STEPS

Positive STEPS

Positive STEPS

Name of Grant

Adaptive intervention strategies trial for strengthening adherence to antiretroviral HIV treatment among youth

Funding Source

National Institute of Nursing Research (1R01NR017098-01)

Pls

Mimiaga and Garofalo

Background

A significant and growing population of young people are acquiring and living with HIV in the US. An estimated >12,200 adolescents were diagnosed with HIV infection in 2010, a 22% increase since 2008(1). Although HIV can be managed with ongoing antiretroviral therapy (ART), exceptionally high levels of adherence are required. Our recently published systematic literature review found that of the 21 articles published that reported data on medication adherence in HIV infected adolescents, seven described pilot interventions to enhance medication adherence; and only two utilized education / counseling sessions to promote adherence skills-building – a component that has shown to be necessary to improving adherence among HIV-infected adults. To our knowledge, there are no demonstrated efficacious ART adherence interventions for HIV infected adolescents to date. This is particularly concerning given that overall rates of adherence among adolescents is generally suboptimal.

Overview of Proposal

This proposal is culmination of 6 years of formative work with this population, including conducting two pilot randomized controlled trials (RCT). The current study is to test the efficacy of a stepped-care “adaptive” ART adherence intervention (“Positive STEPS”) for HIV infected adolescents, ages 16 to 24. Stepped care is a healthcare delivery model in which the least resource intensive part of an intervention is delivered first, and only those who do not improve then receive the high intensity, more resource intensive part of an intervention.

Conceptual Model

The conceptual model is based on our formative work that led to the development of a theoretically-driven intervention curriculum (“Positive STEPS”), grounded in the social and contextual realities of HIV infected adolescents. Our intervention begins with 2-way daily text messaging aimed at improving ART adherence. For many adolescents (over 1/3 from our pilot RCT), text messaging is not sufficient to overcome the barriers to ART adherence. These individuals will then also receive the more intensive component based on general principles of cognitive-behavioral therapy. Informational, problem solving, and cognitive-behavioral “steps” are addressed over 5, in-person, intervention-counseling sessions (incorporating digital video vignettes that are specific to the adherence challenges faced by adolescents).

Overview of Research Plan

192 HIV infected adolescents, aged 16 to 24, and prescribed ART will be recruited in two major U.S. cities with excellent access to and research experience with the population. Participants will be equally randomized to: (1) “Positive STEPS” – a stepped care, adherence intervention with integrated technology and counseling; or (2) Standard of Care comparison group. Participants will be followed for one-year post-randomization. The primary outcomes are improvements in measures of ART adherence (i.e., Wisepill, HIV viral load, and self-report); secondary outcomes include improvements in CD4 cell count, HIV symptoms, and quality of life.

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Fostering Resilience Among MSM in India

Fostering Resilience Among MSM in India

Fostering Resilience Among MSM in India

Fostering Resilience to Psychosocial and HIV Risk in Indian MSM, 2014-2021

MPI: Safren & Mimiaga

National Institute of Mental Health (R01MH100627-01A1)

This was a randomized controlled efficacy trial of an HIV risk reduction group and individual counseling intervention that uses principles of cognitive behavioral therapy and emphasizes the importance of self-acceptance among MSM in Chennai and Mumbai, India.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper
Protocol Paper
Secondary Outcome Paper 1
Secondary Outcome Paper 2
Secondary Outcome Paper 3

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Selected Completed Studies
PASSOS POSITIVOS

PASSOS POSITIVOS

PASSOS POSITIVOS

Name of Grant

Making universal, free-of-charge antiretroviral therapy work for sexual and gender minority youth in Brazil

Funding Source

National Institute of Mental Health (R34 MH126894-01)

Pls

Matthew Mimiaga and Katie Biello

Background

Sexual and gender minority (SGM) youth account for the largest number of incident HIV infections in Brazil. Although HIV can be managed with ongoing antiretroviral therapy (ART), exceptionally high levels of adherence are required. Brazil has implemented a comprehensive HIV treatment program with broad access to ART, but this program does not specifically address barriers to optimal ART adherence, particularly for SGM youth who experience many challenges taking their medication as prescribed.

Overview

This application seeks to develop and pilot test a theory-based, integrated technology and counseling intervention to improve ART adherence among HIV infected SGM youth (ages 15-24) in Rio de Janeiro, Brazil. The intervention aims to improve social support, self-efficacy for taking ART, and teach skills for problem-solving barriers to promote better adherence. To inform the content, structure, and format of the proposed intervention, the MPIs recently conducted focus groups with SGM youth (N = 18) and key informant interviews (N = 7) with medical providers and staff at local HIV service organizations working closely with SGM youth in Rio de Janeiro. Across focus groups and key informant interviews there was universal agreement that an intervention should capitalize on and enhance social support structures among SGM youth, and address their specific concerns, especially as related to the individual (e.g., ART side effects, mood, substance use), social (e.g., HIV/SGM stigma), and structural (e.g., clinic hours, transportation challenges) barriers that they regularly face.

Theoretical Model

The intervention is guided by Social Cognitive and Social Support Theories and is grounded in the social and contextual realities of SGM youth living with HIV in Brazil. Specifically, social support is emphasized and informational, problem-solving and cognitive-behavioral “steps” are addressed over 4-group adherence counseling sessions, which include short video vignettes that seek to normalize adherence challenges. In addition, daily tailored SMS text messages are delivered as part of the intervention to facilitate social-cognitive cues to take medications as prescribed.

Research Plan

Phase 1: Refine and enhance participant acceptability of the intervention and resolve any issues with intervention delivery/implementation; this will be achieved by convening and obtaining feedback from our youth community advisory board throughout this phase and subsequent phases; and by conducting an open-phase pilot with up to 12 SGM youth, with post-intervention exit interviews, as well as obtaining feedback from our youth community advisory board throughout this and subsequent phases. Phase 2: Examine, in a pilot randomized controlled trial, the feasibility, acceptability and potential impact of the proposed intervention among 72 SGM youth who will be equally randomized to the intervention or a time- and attention-matched control condition with standard of care. The outcomes are improved ART adherence (Wisepill, pharmacy assessment and self-report), retention in care and viral load suppression. Study assessments will be conducted at baseline, 3- and 6-months.sss

 

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Project LifeSkills

Project LifeSkills

Project LifeSkills

HIV Prevention Intervention for Young Transgender Women, 2011-2016

MPI: Garofalo & Mimiaga; Co-Is: Kuhns & Reisner

National Institute of Mental Health (R01MH094323-01)

Randomized clinical efficacy trial of Project LifeSkills, a group-delivered, behavioral HIV prevention intervention, vs standard of care conducted among 190 sexually active YTW between March 26, 2012, and August 15, 2016, at community-based locations in Boston, Massachusetts, and Chicago, Illinois, to reduce sexual risk for HIV acquisition or transmission.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:

Primary Outcome Paper
Protocol Paper
Administrative Supplement Paper
Secondary Outcome Paper 1
Secondary Outcome Paper 2
Secondary Outcome Paper 3
Secondary Outcome Paper 4
Secondary Outcome Paper 5
Secondary Outcome Paper 6
Secondary Outcome Paper 7
Secondary Outcome Paper 8
Secondary Outcome Paper 9
Secondary Outcome Paper 10
Secondary Outcome Paper 11
Secondary Outcome Paper 12
Secondary Outcome Paper 13
Secondary Outcome Paper 14


Mobile Adaptation and Testing of a Uniquely Targeted HIV Intervention for Young Transgender Women, 2019-2020

MPIs: Kuhns & Mimiaga

National Institute of Mental Health (R56MH113684-01)

The group-based LifeSkills intervention was adapted to a mobile app, LifeSkills Mobile, with input from an expert advisory group and feedback from YTW collected during user-centered design sessions. A beta version of the app was then tested in a usability evaluation using a think-aloud protocol with debriefing interviews, recordings of screen activity, and assessments of usability

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper

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Selected Completed Studies
Project IMPACT Pilot

Project IMPACT Pilot

Project IMPACT Pilot

Behavioral Activation and HIV Risk Reduction for MSM with Crystal Meth Abuse, 2011-2015

PI: Mimiaga

National Institute on Drug Abuse (R34DA031028-01)

Findings provide further evidence of feasibility and acceptability, and demonstrate initial efficacy for reducing sexual risk for HIV and crystal methamphetamine use in a pilot RCT.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper
Protocol Paper


Behavioral Activation and HIV Risk Reduction for MSM with Crystal Meth Abuse, 2008-2010

PI: Mimiaga

National Institute on Drug Abuse (R03DA023393-01)

Findings provide evidence of feasibility and acceptability, and demonstrate initial efficacy for reducing sexual risk for HIV and crystal methamphetamine use in an open pilot trial.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper

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Selected Completed Studies
Project REWARD

Project REWARD

Project REWARD

Sustaining Effects of Contingency Management on Stimulant Use In HIV-Infected Persons, 2011-2014

MPI: Mimiaga & Mitty

Harvard Center for AIDS Research Award

We developed and implemented a combined contingency management (CM) and behavioral activation intervention aimed at HIV-infected individuals who are engaged in HIV care and currently dependent on crack, cocaine, or methamphetamine. Findings provide evidence of feasibility and acceptability, and demonstrate initial efficacy for  improvements in ARV medication adherence.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:

Primary Outcome Paper

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Selected Completed Studies
Positive STEPS

Positive STEPS

Positive STEPS

Improving Antiretroviral Medication Adherence Among HIV-Infected Youth, 2011-2013
PI: Mimiaga
Harvard Center for AIDS Research Award
This study adapted the Life-Steps intervention designed by our group for HIV-infected adults to be responsive to the needs of HIV-infected adolescents. Following an intervention development phase involving qualitative interviews with 30 adolescents, we conducted an RCT pilot of the intervention among 30 HIV-infected adolescents.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper 1
Primary Outcome Paper 2
Secondary Outcome Paper
Protocol Paper
Description of the Intervention Paper

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Selected Completed Studies
Stronger Together

Stronger Together

Stronger Together

CVCTPlus: A Couples-Based Approach to Linkage to Care and ARV Adherence, 2013-2018

MPI: Mimiaga, Stephenson & Garofalo

National Institute of Child Health and Human Development (R01HD075655-01A1)

We conducted a randomized controlled efficacy trial of a behavioral intervention that included CVCT combined with dyadic adherence counseling (“CVCTPlus”) to improve linkage to care, retention in care, ART adherence and viral suppression among 250 (total N = 500) HIV serodiscordant male-male couples across Atlanta, Boston, and Chicago. Findings demonstrated efficacy for improving HIV care continuum outcomes.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper
Protocol Paper
Description of the Intervention Paper
Secondary Outcome Paper 1
Secondary Outcome Paper 2
Secondary Outcome Paper 3
Secondary Outcome Paper 4
Secondary Outcome Paper 5
Secondary Outcome Paper 6
Secondary Outcome Paper 7
Secondary Outcome Paper 8
Secondary Outcome Paper 9
Secondary Outcome Paper 10

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Selected Completed Studies
NEXUS Study

NEXUS Study

NEXUS Study

HIV Risk for MSM Sex Workers: A Social, Sexual and Drug Network Simulation Study, 2013-2016

MPI: Mimiaga & Biello

National Institute on Drug Abuse (R21DA035113-01A1)

This was a longitudinal epidemiological study of MSM sex worker networks in Massachusetts and Rhode Island to identify protective and risk factors that affect HIV transmission dynamics. Longitudinal data enhanced our understanding of how contemporary social, sexual, and drug abuse network characteristics contribute to increased HIV and STI spread among male sex workers.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper 1
Primary Outcome Paper 2
Primary Outcome Paper 3
Secondary Outcome Paper 1
Secondary Outcome Paper 2
Secondary Outcome Paper 3
Secondary Outcome Paper 4
Secondary Outcome Paper 5


HIV Risk Among Male Sex Workers in New England

PI: Mimiaga

The Fenway Institute, Fenway Health Seed Award

This was a formative study to lay the groundwork for a larger network-based study of male sex workers.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper 1
Primary Outcome Paper 2
Primary Outcome Paper 3

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Selected Completed Studies
Inkwari: Umlazi, Durban, SA

Inkwari: Umlazi, Durban, SA

Inkwari: Umlazi, Durban, SA

Inkwari: An Emerging High-Risk Place Potentiating HIV Spread Among Young Adults in a Hyper-Endemic South African Setting, 2011-2014

PI: Mimiaga

Ragon Institute of MGH, MIT and Harvard Scholars Award

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper
Secondary Outcome Paper 1
Secondary Outcome Paper 1

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Selected Completed Studies
Whoonga: Recreational ARVs South Africa

Whoonga: Recreational ARVs South Africa

Whoonga: Recreational ARVs South Africa

Epidemiology of HIV Antiretroviral Exposure from Whoonga Use in South Africa, 2015-2018

MPI: Grelotti & Mimiaga

National Institute on Drug Abuse (R21DA039857-01)

Some people are exposed to HIV antiretroviral medication through recreational use. This emerging phenomenon poses a significant obstacle to efforts to address the global HIV pandemic. Any antiretroviral exposure from recreational use may increase rates of antiretroviral-resistant HIV strains. This and any diversion of antiretroviral medication for recreational use will increase the cost of delivering this life-saving care. The proposed research will document antiretroviral exposure from the use of whoonga, a drug cocktail in South Africa that may contain antiretroviral medication and illicit drugs. It will also inform future research to link recreational antiretroviral use to antiretroviral resistance among HIV-infected individuals who have yet to initiate HIV treatment, as well as promote the design of culturally appropriate interventions.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper
Formative Paper 1
Formative Paper 2
News Related Article

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Selected Completed Studies
Men’s Small Group Vietnam

Men’s Small Group Vietnam

Men’s Small Group Vietnam
  1. Sexual Health Needs of Male Sex Workers in Ho Chi Minh City, Vietnam, 2010-2012 MPI: Colby & Mimiaga
    Harvard Catalyst Pilot Grant (UL1RR025758-01)

    The aim of this study was to conduct formative research to better understand risk and protective factors for HIV/STI transmission among MSW in Ho Chi Minh City.


  2. Group Based HIV Prevention Intervention for MSW In Ho Chi Minh City, Vietnam 2013-2016

    MPI: Mimiaga & Colby

    Centers for Disease Control and Prevention – Vietnam

    This was a pilot trial of a group-based manualized HIV prevention intervention, focused on barriers to HIV risk reduction and problem solving/skills building. The intervention consisted of 4 group sessions facilitated by trained MSM peer health educators.

    PUBLISHED SCIENTIFIC JOURNAL ARTICLES:

    Primary Outcome Paper
    Formative Paper 1
    Formative Paper 2
    Formative Paper 3
    Formative Paper 4
    Formative Paper 5
    Formative Paper 6
    Formative Paper 7

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Selected Completed Studies
Testing Brief Messages

Testing Brief Messages

Testing Brief Messages

Testing Brief Messages for Black & Latino MSM: Emerging HIV Prevention Options, 2012-2015 

PI: Mimiaga

Centers for Disease Control and Prevention / National Center for HIV, Viral Hepatitis, STDs, and TB Prevention (U01PS0053307-01)

This study included Black and Latino MSM in three major US cities—Chicago, Fort Lauderdale, and Kansas City— with variation in HIV serostatus and sexual risk behavior. Brief health messages of biomedical (e.g., PrEP, PEP, ARVs for treatment) and behavioral (e.g., condoms, serosorting) HIV prevention options were created through extensive qualitative interviews, key informant interviews, and focus groups with these populations. These data were used to refine the messages per participant and expert feedback, and to ensure comprehension of information / health literacy, clarity, increase in knowledge, and potential to influence behaviors and attitudes. Through an iterative approach, the messages were further refined and finalized. The final phase tested the brief messages (delivered via text message) on health behavior change among 1500 Black and Latino MSM in the same three cities. The primary aim of this project was to assess changes in behaviors and attitudes, feasibility of message delivery, and acceptability of message content.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper
Secondary Outcome Paper 1
Secondary Outcome Paper 2
Secondary Outcome Paper 3
Secondary Outcome Paper 4
Secondary Outcome Paper 5
Secondary Outcome Paper 6
Secondary Outcome Paper 7

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Selected Completed Studies
Club Drugs & PrEP

Club Drugs & PrEP

Club Drugs & PrEP

Understanding PrEP Implementation Among Club Drug Using MSM, 2011-2014

MPI: Mimiaga & Mitty

National Institute of Mental Health (R21MH095535-01)

This study reports finding on PrEP implementation approached among club drug using MSM.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper 1
Primary Outcome Paper 2
Primary Outcome Paper 3

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Selected Completed Studies
mHealth Male Sex Workers India

mHealth Male Sex Workers India

mHealth Male Sex Workers India

Technology For HIV Prevention Among Vulnerable Men in India, 2011-2015
PI: Mimiaga
National Institute on Drug Abuse (R21DA03372-01)
We first conducted qualitative interviews and focus groups to inform the content, structure and format of an HIV risk reduction intervention for male sex workers in India. We then conducted an open pilot of the intervention and assessed initial feasibility and acceptability. Next, we conducted a pilot randomized controlled trial of a mobile phone delivered HIV prevention intervention among this group.

PUBLISHED SCIENTIFIC JOURNAL ARTICLES:
Primary Outcome Paper 1
Primary Outcome Paper 2
Secondary Outcome Paper

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Selected Completed Studies
Fostering Resilience

Fostering Resilience

Fostering Resilience

Name of Grant

Fostering resilience to psychosocial and HIV risk in Indian MSM

Funding Source

National Institute of Mental Health (R01MH100627-01A1)

Pls

Mimiaga and Safren

Background

India has the world’s third largest HIV epidemic1, and given the population size, one of the largest, if not the largest, populations of men who have sex with men (MSM) in the world. MSM in India have an estimated seroprevalence of 14.7%. HIV prevention efforts for MSM in India are limited to condom distribution and HIV education, with no existing efficacy trials of interventions and therefore no evidenced based interventions this population. They are hidden, stigmatized, and face considerable psychosocial stressors, including pressure to marry, which increases the risk for HIV transmission to their wives. This proposal is the culmination of our ongoing, successful > 10-year community-based research collaboration with two NGOs dedicated to HIV prevention among MSM, Sahodaran (Chennai) and The Humsafar Trust (Mumbai), and investigators from the India Council of Medical Research (ICMR), National Institute for Research in Tuberculosis (NIRT) in Chennai. We have, in every phase of the development of this proposal (and throughout each of our preliminary studies), engaged the community in developing the research ideas, forming the program of research, designing / refining the studies, and disseminating the results to inform next-steps. Preliminary studies include: 1) documenting the exceptionally high rates of distress / mental health problems in MSM in Mumbai, 2) documenting, in Chennai, the high prevalence of HIV and sexual risk, and the important surrounding psychosocial context, 3) conducting a three-phased Indo-U.S. sponsored R21 including extensive formative work from CABs, focus groups with representative MSM, and key informant interviews to develop our self-acceptance based model of self-care in the context of pervasive stigma and discrimination facing Indian MSM. We field tested and then conducted a feasibility pilot RCT (with CAB feedback throughout) of the resulting intervention comparing it to HIV voluntary counseling and testing (VCT) alone. This field test and pilot RCT showed high participant acceptability and feasibility of study procedures, and success reducing HIV sexual risk behavior.

Design

MSM in Chennai and Mumbai will be randomized to either: 1) a self-acceptance based HIV sexual risk reduction intervention and HIV/STI VCT, or 2) HIV/STI VCT. Those randomized to the experimental intervention will receive 4 group sessions focused on building self-acceptance, social support and HIV risk reduction skills and 6 individual sessions focused on personalized HIV risk reduction plans and, as needed, prevention case management. Participants will be followed for one year, with STI incidence and HIV risk behavior as primary outcomes and psychosocial mediators secondary. Cost effectiveness of the intervention will be calculated compared to HIV/STI VCT alone, considering individual and public health benefits as well as downstream cost-savings due to infections averted.

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IMPACT – ATN 170

IMPACT – ATN 170

IMPACT - ATN 170

Name of Grant

Hybrid Type 2 Effectiveness-Implementation Trial of Status Neutral, Integrated Behavioral Activation and Risk Reduction Intervention for Stimulant Use Among Sexually Active Young GBMSM

Funding Source

National Institute of Child Health and Human Development / Adolescent Medicine Trials Network for HIV Interventions (ATN170)

Pls

Mimiaga and Biello

Background

Stimulant (e.g., crystal methamphetamine, cocaine, ecstasy, MDMA) use is a substantial public health problem among young gay, bisexual and other men who have sex with men (YGBMSM) in the United States (US); the prevalence of past-year use is 2x greater among YGBMSM compared to their heterosexual counterparts. Use of stimulants may lead to behavioral disinhibition and facilitate, prolong, and enhance sexual activity, contributing to increased engagement in sexual risk behaviors, including condomless anal sex (CAS), and HIV & STI acquisition and transmission.  In the US, as high as 33% of YGBMSM report having ever used stimulants in the context of sex. Stimulant use often co-occurs with other psychosocial problems (e.g., depression), further increasing HIV vulnerability among YGBMSM. Stimulant use also hinders the use of prevention services, such as uptake/adherence to pre-exposure prophylaxis (PrEP). Similarly, for YGBMSM living with HIV, stimulant use leads to suboptimal antiretroviral therapy (ART) adherence, poor retention in HIV care and unsuppressed viral load, which impedes treatment-as-prevention (TasP) efforts and leads to devastating HIV-related health outcomes

Design

This is a Hybrid Type 2 Effectiveness-Implementation Trial.  The reach and effectiveness of Project IMPACT will be tested in a two-arm, multi-site and multi-format (i.e., in-person and virtual) randomized controlled trial of 360 cisgender YGBMSM who use stimulants in the context of high-risk sex. Project IMPACT, a status neutral, psychosocial intervention that uses behavioral activation (BA)—an evidence-based, cognitive behavior therapy—as a treatment for stimulant use and sexual risk reduction counseling for GBMSM. The experimental condition (BA-RR) is comprised of 10 sessions—one session focused on orienting and rationale, two sessions focused on risk reduction, six sessions integrating BA and risk reduction counseling (including PrEP or ART and HIV care), and one final session on relapse prevention.

 

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Mpox MSM Study

Mpox MSM Study

Mpox MSM Study
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C-LARAH Open House

C-LARAH Open House

C-LARAH Open House

Our open house invited UCLA faculty, staff, students, partners, and community leaders to engage in conversations on sexual and gender minority health. We highlighted the Center’s current research projects, academic training programs, sustained community partnerships, and more!

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Center Events
Inaugural C-LARAH EDI in Research Symposium

Inaugural C-LARAH EDI in Research Symposium

Inaugural C-LARAH EDI in Research Symposium

The first C-LARAH EDI in Research Symposium, in partnership with the EDI Committee in the Department of Epidemiology and the EDI Office at the UCLA Fielding School of Public Health, featured distinguished speaker Dr. Nina Harawa, a Professor of Medicine and Epidemiology at UCLA, and emerging expert James Huynh, currently a PhD candidate in Community Health Sciences at UCLA and an incoming Assistant Professor of Anti-Racist Health Policy at the University of Michigan. Both speakers are renowned for their significant contributions to advancing EDI in public health research, particularly within the context of LGBTQ+ health and well-being.

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Center Events
Pizza & Protection Party

Pizza & Protection Party

Pizza & Protection Party

In partnership with the UCLA AIDS Institute and the UCLA Fielding School of Public Health Office of Equity, Diversity, and Inclusion, C-LARAH hosted the Pizza and Protection Community Event where we offered free flu and COVID-19 vaccinations, sexual health and harm reduction resources, and, of course, pizza!

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Center Events
DoxyPEP for STI Prevention in the Deep South

DoxyPEP for STI Prevention in the Deep South

DoxyPEP for STI Prevention in the Deep South
DoxyPEP in Women for STI Prevention in the Deep South
Funding: National Heart, Lung and Blood Institute (NHLBI) at NIH – UCLA MWCCS Award
PI: Elizabeth Yonko, MPH
Background: Sexually transmitted infections (STIs) are a significant public health concern for cisgender women (women who were assigned female at birth) in the United States, and the Southern US is disproportionately burdened. Untreated bacterial STIs in women can cause pelvic inflammatory disease and lead to infertility in some cases. Additionally, untreated STIs upregulate HIV transmission and acquisition. Doxycycline is an antibiotic that has been investigated for its potential use as post-exposure prophylaxis (PEP) for STIs, a “morning after” pill.  New prevention measures are needed to address the STI epidemic in the US, but most research on this topic has focused on cisgender men who have sex with men (MSM).  Recent studies of doxycycline for STI prevention (DoxyPEP) among MSM and transgender women have demonstrated about a 70% efficacy at preventing chlamydia and syphilis acquisition when taken shortly after exposure, with mixed efficacy for gonorrhea (estimates at ~50%). Studies in cisgender women are limited and show inconsistent results.
Study Overview: Using a mixed methods approach, we aim to understand attitudes and perceived acceptability towards DoxyPEP for STI prevention among women in the Deep South, living with and without HIV. We will synthesize important learnings from focus groups, individual interviews, and quantitative surveys in the MWCCS to propose a theoretical model for DoxyPEP interventions focused on uptake and adherence among women in the Deep South.
We will recruit women who are enrolled in the MACS/ WIHS Combined Cohort Study (MWCCS) and from the Study of Treatment And Reproductive outcomes in women (STAR) at University of Alabama at Birmingham (UAB) or University of Mississippi Medical Center (UMMC), who are 18 years and older, were assigned female sex at birth, and who are sexually active. We have partnered with two community representatives from the UAB and UMMC sites and work closely with UAB/UMMC site investigators to provide feedback on study materials, emerging themes, and an ultimate theoretical model of intervention effects.
Innovation:
This study is one of the first to explore acceptability of DoxyPEP for STI prevention among cisgender women in the U.S., addressing a critical gap in STI prevention research. By focusing on a population often underrepresented in STI prevention trials, this study aims to generate culturally relevant insights that can inform equitable DoxyPEP intervention and implementation strategies.
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World AIDS Day Movie Night

World AIDS Day Movie Night

World AIDS Day Movie Night

To commemorate World AIDS Day 2024, C-LARAH hosted a movie night, screening the 2012 American documentary film about the early years of the HIV/AIDS epidemic and the grassroots movements of Activists, “How to Survive a Plague.” In partnership with the UCLA AIDS Institute, we also provided dinner and sexual health and harm reduction resources.

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Center Events
PUBLICATIONS

Scientific Publications

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New UCLA center to focus on health, safety and well-being of LGBTQ community

New UCLA center to focus on health, safety and well-being of LGBTQ community

New UCLA center to focus on health, safety and well-being of LGBTQ community
Read more: from UCLA Newsroom (more…)
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New, more contagious, COVID-19 strain reaches Southern California

New, more contagious, COVID-19 strain reaches Southern California

New, more contagious, COVID-19 strain reaches Southern California
Read more: from the Daily Bruin (more…)
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The Persistent and Evolving HIV Epidemic in American Men Who Have Sex With Men

The Persistent and Evolving HIV Epidemic in American Men Who Have Sex With Men

The Persistent and Evolving HIV Epidemic in American Men Who Have Sex With Men
Dr. Matthew Mimiaga, UCLA Fielding School of Public Health professor of epidemiology, co-authored a research piece in the journal The Lancet on the ongoing HIV epidemic in this population, using a social-ecological perspective
Date:
Friday, February 19, 2021
Contact:
Dr. Matthew Mimiaga, UCLA Fielding School of Public Health professor of epidemiology, co-authored a research piece in the journal The Lancet on the ongoing HIV epidemic in this population, using a social-ecological perspective. Summary: Men who have sex with men (MSM) in the USA were the first population to be identified with AIDS and continue to be at very high risk of HIV acquisition. We did a systematic literature search to identify the factors that explain the reasons for the ongoing epidemic in this population, using a social-ecological perspective. Common features of the HIV epidemic in American MSM include role versatility and biological, individual, and social and structural factors. The high-prevalence networks of some racial and ethnic minority men are further concentrated because of assortativemixing, adverse life experiences (including high rates of incarceration), and avoidant behaviour because of negativeinteractions with the health-care system. Young MSM have additional risks for HIV because their impulse control is less developed and they are less familiar with serostatus and other risk mitigation discussions. They might benefit from prevention efforts that use digital technologies, which they often use to meet partners and obtain health-related information. Older MSM remain at risk of HIV and are the largest population of US residents with chronic HIV, requiring culturally responsive programmes that address longer-term comorbidities. Transgender MSM are an understudied population, but emerging data suggest that some are at great risk of HIV and require specifically tailored information on HIV prevention. In the current era of pre-exposure prophylaxis and the undetectable equals untransmittable campaign, training of health-care providers to create culturally competent programmes for all MSM is crucial, since the use of antiretrovirals is foundational to optimising HIV care and prevention. Effective control of the HIV epidemic among all American MSM will require scaling up programmes that address their common vulnerabilities, but are sufficiently nuanced to address the specific sociocultural, structural, and behavioural issues of diverse subgroups. Conclusions: Our review has identified several common factors that potentiate the HIV epidemic among all MSM in the USA, including biological vulnerability, unique network characteristics, and internalisation of societal stigma leading to behavioural syndemics, enhanced by the disinhibiting effects of substance use. Growing up in non-affirming environments has health consequences. However, our review has also established that diverse subgroups of MSM exist, with unique racial, ethnic, age- related, and gender identities and needs. Institutional racism and cultural insensitivity will potentiate the increasing disparities in HIV incidence and access to optimal treatment and prevention services. Interventions that can leverage advances in antiretroviral-based treatment and prevention to curtail the domestic epidemic in US MSM will need to attend to the common themes (eg, by integrating behavioural health services with biomedical interventions), but culturally tailored programmes need to be developed to address the specific drivers of HIV risk in the diverse but vulnerable subpopulations. Interventions will need to attend to structural issues, including racism, poverty, homophobia and transphobia, and understand how different age cohorts meet partners and access health information, by considering how to educate and engage MSM in the digital era. Although great progress has been made in recent years, almost half of people with HIV in the USA are not currently virally suppressed on highly active ART, and fewer than a quarter of MSM in the USA who might benefit from PrEP are using it. The disparities in accessing the benefits of therapeutic and preventive advances are particularly egregious for Black and Latino MSM, indicating that much more work remains to be done to develop effective, culturally congruent programmes to addresss these challenges. In the face of many adversities, MSM in the USA have shown resilience, but progress will not happen unless structural and societal issues (eg, racism, access to health insurance, culturally responsive care) are properly addressed.

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Group led by UCLA professor awarded $8.8 million for HIV intervention using mobile app

Group led by UCLA professor awarded $8.8 million for HIV intervention using mobile app

Group led by UCLA professor awarded $8.8 million for HIV intervention using mobile app
Source: from UCLA Newsroom (more…)
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Strengthening Resilience to Reduce HIV Risk in Indian MSM: a Multicity, Randomised, Clinical Efficacy Trial

Strengthening Resilience to Reduce HIV Risk in Indian MSM: a Multicity, Randomised, Clinical Efficacy Trial

Strengthening Resilience to Reduce HIV Risk in Indian MSM: a Multicity, Randomised, Clinical Efficacy Trial
Dr. Matthew Mimiaga, UCLA Fielding School of Public Health professor of epidemiology, co-authored a research piece in the April edition of the journal The Lancet on the HIV epidemic in this population, evaluating a resilience-based psychosocial intervention
Date: Wednesday, March 17, 2021
Dr. Matthew Mimiaga, UCLA Fielding School of Public Health professor of epidemiology, co-authored a research piece in the April edition of the journal The Lancet on the HIV epidemic in this population, evaluating a resilience-based psychosocial intervention. Background Men who have sex with men (MSM) in India are extremely marginalised and stigmatised, and therefore experience immense psychosocial stress. As current HIV prevention interventions in India do not address mental health or resilience to these stressors, we aimed to evaluate a resilience-based psychosocial intervention in the context of HIV and sexually transmitted infection (STI) prevention. Methods We did a multicity, randomised, clinical efficacy trial in Chennai (governmental tuberculosis research institute) and Mumbai (non-governmental organisation for MSM), India. Inclusion criteria were MSM, aged 18 years or older, who were at risk of HIV acquisition or transmission, defined as having any of the following in the 4 months before screening: anal sex with four or more male partners (protected or unprotected), diagnosis of an STI, history of transactional sex activity, or condomless anal sex with a man who was of unknown HIV status or serodiscordant. Participants were required to speak English, Tamil (in Chennai), or Hindi (in Mumbai) fluently. Eligible individuals were randomly assigned (1:1) to either a resilience-based psychosocial HIV prevention intervention, consisting of group (four sessions) and individual (six sessions) counselling alongside HIV and STI voluntary counselling and testing, or a standard-of-care control comprising voluntary counselling and testing alone. The primary outcomes were number of condomless anal sex acts with male partners during the past month (at baseline and 4 months, 8 months, and 12 months after randomisation), and incident bacterial STIs (at 12 months after randomisation). Resilience-related mediators included self-esteem, self-acceptance, and depression. Recruitment is now closed. This trial is registered with ClinicalTrials.gov, NCT02556294. Findings Between Sept 4, 2015, and June 28, 2018, we enrolled 608 participants; 305 (50%) were assigned to the psychosocial intervention condition and 303 (50%) were assigned to the control condition. 510 (84%) of 608 men completed an assessment at 4 months after randomisation, 483 (79%) at 8 months, and 515 (85%) at 12 months. 512 (99%) of 515 men had STI data from the 12-month assessment. The intervention condition had a 56% larger reduction in condomless anal sex acts (95% CI 35–71; p<0·0001) from baseline to 4-month follow-up, 72% larger reduction (56–82; p<0·0001) from baseline to 8-month follow-up, and 72% larger reduction (53–83; p<0·0001) from baseline to 12-month follow-up, compared with the standard-of-care control condition (condition by time interaction; χ2=40·29, 3 df; p<0·0001). Improvements in self-esteem and depressive symptoms both mediated 9% of the intervention effect on condomless anal sex acts. Bacterial STI incidence did not differ between study conditions at 12-month follow-up. Interpretation A resilience-based psychosocial intervention for MSM at risk of HIV acquisition or transmission in India was efficacious in reducing condomless anal sex acts, with evidence for mediation effects in two key target resilience variables. HIV prevention programmes for MSM in India should address mental health resilience to augment reductions in the risk of sexually transmitted HIV. Funding National Institute of Mental Health.

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What We’ve Learned About Disease in the 40 Years Since the Discovery of HIV/AIDS at UCLA

What We’ve Learned About Disease in the 40 Years Since the Discovery of HIV/AIDS at UCLA

What We’ve Learned About Disease in the 40 Years Since the Discovery of HIV/AIDS at UCLA
Read more: from UCLA Health (more…)
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Giving blood has been off limits for many gay men. A new study could help change that

Giving blood has been off limits for many gay men. A new study could help change that

Giving blood has been off limits for many gay men. A new study could help change that
Read more: from the LA Times (more…)
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UCLA Fielding School Professor’s Team Awarded more than $5.2 Million in Grants for HIV Prevention

UCLA Fielding School Professor’s Team Awarded more than $5.2 Million in Grants for HIV Prevention

UCLA Fielding School Professor’s Team Awarded more than $5.2 Million in Grants for HIV Prevention
Read more: from UCLA Newsroom (more…)
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UCLA-led team awarded more than $5 million for HIV prevention projects

UCLA-led team awarded more than $5 million for HIV prevention projects

UCLA-led team awarded more than $5 million for HIV prevention projects
Read more: from UCLA Newsroom (more…)
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UCLA Public Health Summer 2021 Issue: Promoting Public Health for the LGBTQ Population

UCLA Public Health Summer 2021 Issue: Promoting Public Health for the LGBTQ Population

UCLA Public Health Summer 2021 Issue: Promoting Public Health for the LGBTQ Population
Read more: from UCLA FSPH Public Health Magazine (more…)
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UCLA Fielding School Center for LGBTQ+ Advocacy, Research & Health Marks Its First Year

UCLA Fielding School Center for LGBTQ+ Advocacy, Research & Health Marks Its First Year

UCLA Fielding School Center for LGBTQ+ Advocacy, Research & Health Marks Its First Year
Read more: from UCLA FSPH News
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Want to See More of C-LARAH in the News?

Want to See More of C-LARAH in the News?

Want to See More of C-LARAH in the News?
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Press Release
Community discusses revised blood donor criteria for men who have sex with men

Community discusses revised blood donor criteria for men who have sex with men

Community discusses revised blood donor criteria for men who have sex with men
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UCLA Public Health 60th Anniversary Issue: Learning From Outbreaks

UCLA Public Health 60th Anniversary Issue: Learning From Outbreaks

UCLA Public Health 60th Anniversary Issue: Learning From Outbreaks
Read more: from UCLA FSPH Public Health Magazine (more…)
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MWCCS Winter 2024-25 Newsletter

MWCCS Winter 2024-25 Newsletter

MWCCS Winter 2024-25 Newsletter
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Trump’s ban on funds to ‘promote gender ideology’ could threaten hundreds of NIH research projects

Trump’s ban on funds to ‘promote gender ideology’ could threaten hundreds of NIH research projects

Trump’s ban on funds to ‘promote gender ideology’ could threaten hundreds of NIH research projects
Read more: from Science
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March 2025 Events

March 2025 Events

March 2025 Events
March 10: National Women & Girls HIV/AIDS Awareness Day March 20: National Native HIV/AIDS Awareness Day March 31: International Transgender Day of Visibility We are celebrating at C-LARAH: March is a significant month for raising awareness about HIV and promoting visibility for marginalized communities. On March 10, National Women & Girls HIV/AIDS Awareness Day highlights the unique challenges faced by women and girls in the fight against HIV/AIDS, emphasizing the need for tailored prevention and treatment strategies. This is followed by National Native HIV/AIDS Awareness Day on March 20, which focuses on the impact of HIV/AIDS within Native communities and advocates for culturally relevant resources and education. Finally, March 31 marks International Transgender Day of Visibility, celebrating transgender individuals while also raising awareness about the disparities they face, including those related to HIV/AIDS. Together, these observances foster understanding and advocacy for improved health outcomes across wonderfully diverse populations!
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New Featured Statement: Pride 2025

New Featured Statement: Pride 2025

New Featured Statement: Pride 2025
Pride is not just a celebration—it is a call to action. At the UCLA Center for LGBTQ+ Advocacy, Research & Health (C-LARAH), we answer that call by working in partnership with the LGBTQ+ community to confront inequities, advance social justice, and reimagine what is possible in LGBTQ+ research, health and well-being. We understand that the struggle for liberation remains ongoing, and that those most affected by systemic injustices must be at the forefront of creating meaningful change. From transgender and nonbinary individuals, to LGBTQ+ people of color, immigrants, and those living with or at risk for HIV—our efforts are rooted in the communities whose health, dignity, and voices have historically been marginalized or ignored. We find strength in the proud legacy of resistance pioneered by Black and Brown transgender women and queer organizers, whose unwavering courage made Pride possible as a protest. Their bravery continues to inspire us to pursue research that transforms lives, advocacy grounded in social justice and equity, and collaborative partnerships built on genuine care and respect. Pride is an act of resistance. Pride embodies resilience. Pride is a celebration of unapologetic queer joy. In a world that too often seeks to erase our existence, embracing joy becomes a revolutionary act—and collective joy is our most powerful solution. At C-LARAH, we believe that dedicated effort is meaningful effort—and that it can be infused with joy. Because when we unite, we are stronger and more resilient. Happy Pride—today and every day—from all of us at C-LARAH. Read More Statements
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Symposium discusses social, health challenges facing LGBTQ+ community

Symposium discusses social, health challenges facing LGBTQ+ community

Symposium discusses social, health challenges facing LGBTQ+ community
Read more: from the Daily Bruin (more…)
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New Featured Community Highlight: Dr. Yuhang Qian, PhD

New Featured Community Highlight: Dr. Yuhang Qian, PhD

New Featured Community Highlight: Dr. Yuhang Qian, PhD
Congratulations to Dr. Yuhang Qian for completing his PhD in Epidemiology at UCLA! Your achievement is an inspiration, and we look forward to your future successes! See More Community Highlights
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Community Highlights
New Featured Event: The 2nd Annual EDI in Research Symposium

New Featured Event: The 2nd Annual EDI in Research Symposium

New Featured Event: The 2nd Annual EDI in Research Symposium

On March 18, 2025, 70 attendees from UCLA and the broader community gathered for our 2nd Annual C-LARAH EDI in Research Symposium, with the theme of Advancing LGBTQ+ Health and Resilience in This Moment of Deepening Political Adversity. The event featured two distinguished speakers: renowned scholar Dr. Ilan Meyer from the UCLA School of Law and Williams Institute, and rising epidemiologist and Fielding doctoral researcher Elizabeth Yonko.

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UCLA-led study is the first to establish efficacy of a behavioral intervention to enhance HIV treatment outcomes among youth living with HIV

UCLA-led study is the first to establish efficacy of a behavioral intervention to enhance HIV treatment outcomes among youth living with HIV

UCLA-led study is the first to establish efficacy of a behavioral intervention to enhance HIV treatment outcomes among youth living with HIV

Read more: from UCLA Newsroom

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Featured Event: UCLA Spring Grad LGBTQ+ Pride Mixer

Featured Event: UCLA Spring Grad LGBTQ+ Pride Mixer

Featured Event: UCLA Spring Grad LGBTQ+ Pride Mixer

On June 6th, 2025, C-LARAH co-sponsored the Inaugural UCLA Spring Grad LGBTQ+ Pride Mixer—a celebration of Unapologetic Joy. This special event honored both the end of the academic year and the beginning of Pride Month, creating a vibrant and affirming space for LGBTQ+ and allied graduate students from across UCLA to come together, connect, and celebrate. In a time when queer joy is both necessary and revolutionary, this mixer centered visibility, community, and celebration across disciplines and identities.

Designed as a cocktail-style gathering, the event featured music, complimentary food and an open bar, rainbow-themed giveaways, and a keynote speaker Freddy Puza, the Vice Mayer of Culver City.

This event was proudly hosted by OUT@Fielding, Out@Anderson, the Center for LGBTQ+ Advocacy, Research and Health (C-LARAH), the Graduate Student Association (GSA), the Graduate Student Resource Center (GSRC), and the Pride Alliance at DGSOM, with additional support from UCLA’s wider graduate, LGBTQ+, and equity, diversity, and inclusion (EDI) community.

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New Featured Statement: Honoring Juneteenth

New Featured Statement: Honoring Juneteenth

New Featured Statement: Honoring Juneteenth
Honoring Juneteenth: A Day of Freedom, Reflection, and Resistance Today, on Juneteenth, the UCLA Center for LGBTQ+ Advocacy, Research & Health (C-LARAH) honors the enduring legacy of Black freedom fighters who have paved the way toward liberation, justice, and equity in the face of systemic oppression. June 19, 1865 — more than two years after the Emancipation Proclamation — marked the delayed freedom of enslaved Black Americans in Galveston, Texas. Juneteenth is not just a commemoration of emancipation, but a reminder of the ongoing struggle for Black liberation across all systems and institutions. As a center rooted in public health, advocacy, and justice, we affirm that Black Lives Matter and that the health and well-being of Black LGBTQ+ individuals must remain central in our work. The intersecting legacies of racism, homophobia, and transphobia continue to shape lived experiences, and we remain committed to dismantling those barriers through research, policy, and community-rooted care. Today, we reflect, recommit, and raise our voices in solidarity. Juneteenth is a call to action — to imagine and fight for a future where freedom is truly for all. In community and with purpose, The UCLA Center for LGBTQ+ Advocacy, Research & Health (C-LARAH) Read More Statements
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